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br LO and the secretase complex Supporting
2024-01-25
5LO and the γ-secretase complex Supporting this concept, during a recent trial testing the γ-secretase inhibitor semagacestat (LY 450139), AD patients actually experienced a functional decline compared to patients who took a placebo in addition to several other significant adverse effects (Doody
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Stroke also known as a
2024-01-24
Stroke, also known as a cerebrovascular accident or O-propargyl-puromycin australia attack, is one of the leading causes of death and disability worldwide (Haley et al., 2017; Hankey, 2017; Lie et al., 2017). According to the data released by the World Health Organization (WHO), stroke occurs every
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br Results br Discussion br Conclusion The flux of glucose
2024-01-24
Results Discussion Conclusion The flux of glucose into cytosolic short chain acyl-CoAs was maintained in pure beta 5-Azacytidine in the presence of inhibition of ATP citrate lyase with hydroxycitrate and also in a cell line with >90% ATP citrate lyase knockdown suggesting that a pathway ot
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TLX may promote survival and prevent apoptosis in NB cells
2024-01-24
TLX may promote survival and prevent apoptosis in NB S1RA [12]. Here, we ask whether the survival-promoting effects of TLX are mediated by Apoptosis Signal-regulating Kinase-1 (ASK1, MAP3K5). ASK1 is a member of the Mitogen-Activated Protein (MAP) kinase family and it preferentially activates the J
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1-NM-PP1 To enhance the accuracy of SEs
2024-01-24
To enhance the accuracy of SEs in eliminating cancer cells, the mAb recognized by specific 1-NM-PP1 on tumor cells were fused with SEs. Fab C215 or C242 fused with SEA promoted apoptosis in human colon carcinoma cells via Fas (Dohlsten et al., 1994, Litton et al., 1996). SEB-incorporated exosomes we
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Although the role of apelin and APJ
2024-01-24
Although the role of apelin and APJ receptor in cardiovascular functions has been well-elucidated, little is known for the effect of the central apelinergic system on gastrointestinal (GI) functions. In mice, it has been found previously that central exogenous apelin-13 decreased gastric emptying (G
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LOXs and CYPs are a series of iron containing
2024-01-24
LOXs and CYPs are a series of iron-containing enzymes that metabolize arachidonic PNU-120596 to form biologically active products, such as epoxyeicosatrienoic acids (EETs) hydroperoxyeicosatetraenoic acids (HETEs), prostaglandins, leukotrienes and thromboxanes [6]. Among these mediators, 12/15LOX ha
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In pancreatic islets we found an increase in protein
2024-01-24
In pancreatic islets we found an increase in protein expression of leukocyte 12/15-LO that paralleled the metabolic decline characterized by severe hyperglycemia and reduced islet numbers. Similar increase in 12/15-LO expression by Western blot was found in the control mice, which have a normal meta
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br Discussion Missense mutations transversions of the first
2024-01-24
Discussion Missense mutations (transversions) of the first nucleotide of the phenylalanine bromfenac at position 1174 (F1174) of the anaplastic lymphoma kinase gene can result in substitutions to leucine or valine (F1174L/V) while missense mutation (transversion) of the second nucleotide of the
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APPL is highly expressed in pancreatic cells
2024-01-24
APPL1 is highly expressed in pancreatic β cells, but its levels are significantly decreased in several mouse models of obesity and diabetes, including HFD-induced obese mice and db/db mice [6], [73], suggesting that the dysregulation of APPL1 may be associated with malfunction of the pancreas in obe
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The sequence of our reconstructed Anc is inferred
2024-01-23
The sequence of our reconstructed βAnc is inferred based on probabilities, and the estimated probability of inferring the actual ancestral sequence is the product of the posterior probabilities for each site within the reconstructed sequence. Although the posterior probabilities (PP) for the majorit
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br Acknowledgements MC and PD
2024-01-23
Acknowledgements MC and PD were funded by the Michael J Fox Foundation (Grant ID 9969). We would like to thank Pierluigi Saba, Francesco Traccis and Barbara Tuveri for their technical assistance. Introduction In the prostate, androgens play a crucial role in normal, BPH and cancerous growth b
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Introduction hydroxytryptamine HT is found throughout
2024-01-23
Introduction 5-hydroxytryptamine (5-HT) is found throughout the body and influences smooth muscle activity in various tissues including the intestine, vasculature and urinary Ro3306 (Kim and Camilleri, 2000, Klarskov and Horby-Petersen, 1986, Mohammad-Zadeh et al., 2008). The current classification
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ack1 inhibitors Young disease transitioning B Sle mice show
2024-01-23
Young disease-transitioning B6·Sle1 mice show partial loss of leukocyte Axl versus B6 controls (data not shown). Further, BMDM from diseased B6·Sle1.Yaa mice do not express detectable levels of ADAM10 and TACE (ADAM17) but do express basal levels of Axl similar to wild type B6-derived BMDM (Suppleme
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Demonstration of in vivo efficacy of potential chemopreventi
2024-01-23
Demonstration of in vivo efficacy of potential chemopreventive agents in animal models is necessary for their clinical development. Our present study provides experimental evidence that CuB 0.1μmol by oral administration (for 2weeks before the cancer cell injection, 5days per week) significantly inh
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