Epigallo catechin gallate EGCG the most abundant component in

Epigallo catechin gallate (EGCG), the most abundant component in green tea (Camellia sinensis), has potent antioxidant activity. It has been shown that EGCG reduces the H2O2-induced generation of reactive oxygen species (ROS), and prevents the loss of mitochondrial membrane potential (Δψm), and the release of cytochrome c from the mitochondria into the cytosol. Epigallocatechin gallate inhibits the activities of caspase-9 and caspase-3 and thus prevents intrinsic apoptosis. There are many other polyphenols such as flavonoids, phenolic acids, phenolic alcohols, stilbenes and lignans which act as dietary antioxidants and are thus effective in apoptosis inhibition. Polyphenols are major constituents of fruits, vegetables, grains, roots, chocolate, coffee, tea, and wine.
Grape seed extract (GSE) is a dietary supplement that acts as potent antioxidant and free radical scavenger by influencing various signaling pathways and therefore beneficial in preventing cataracts. GSE contains 70–95% standardized proanthocyanidins (class of phenolic compounds). The seeds of the grape are particularly rich source of proanthocyanidins. NF-кB is transcription factor that regulates various genes including apoptosis, cell adhesion, proliferation, inflammation, and cellular-stress response. In un-stimulated or normal cells, NF-кB remains in the cytoplasm as an inactive complex with inhibitor kappa B. Pathogenic stimuli like free radicals activate NF-кB and causes its phosphorylation. After phosphorylation there is subsequent release of inhibitor kappa B, resulting in translocation of NF-кB to the nucleus followed by binding to DNA control elements that influence the transcription of certain specific genes. ultimately resulting in cell apoptosis. However, it has been shown that grape seed extract reduces the generation of ROS induced by H2O2 as well as translocation of NF-кB in lens epithelial buy Cycloheximide ultimately inhibiting apoptosis.
Resveratrol (RES) is a naturally occurring polyphenol that decreases production of ROS and increases protection against oxidative stress. RES has been shown to suppress apoptosis of lens epithelial cells and hence prevents cataract formation.Table 6 cites some dietary sources of resveratrol.
Coenzyme Q10 (ubiquinone) is a vitamin-like benzoquinone compound that acts as free radical scavenger. It prevents light induced apoptosis in human lens epithelial cells. Sources of coenzyme Q10 are mentioned in Table 7. Common nutraceuticals used in market and their common mechanism of actions are listed in Table 8 and Fig. 1.


Conflict of interest


Glaucoma is a neuro-degenerative disorder characterized by wide-spread loss of retinal ganglion cells (RGC). This RGC demise occurs through apoptosis which is a cascade of cellular events leading to programmed cell death. Apoptosis of RGCs is an early and critical event in the evolution of glaucomatous visual field loss. However, it is well known that up to 20–40% of the RGCs might already be lost before the visual field defects become apparent. This leads to an unfortunate 10-year delay in the diagnosis of glaucoma.
Recently, a promising new technology has been reported to detect RGC apoptosis in vivo. This technique is known as “Detection of Apoptosing Retinal Cells” (DARC). With the application of this method it will be possible to identify patients prior to the onset of irreversible vision loss. Apart from diagnosis of glaucoma suspects, it will also provide a rapid and objective assessment of the effectiveness of clinical intervention in the patient and shorten the period of clinical trials.

RGC loss in glaucoma is an important early step. RGC demise is initiated due to a pathological event, such as ischemia, axonal injury or changes in the lamina cribrosa activating apoptosis. This is a type of programmed cell death characterized by a carefully coordinated collapse of cellular architecture associated with protein degradation and de-oxy ribonucleic acid (DNA) fragmentation. This process is seen in a large variety of tissues during the life cycle of the individual. It includes a genetically programmed destruction of specific cell lines during embryogenesis, hormone-dependent physiologic involution (such as the endometrium during the menstrual cycle), cell death of populations (like the intestinal epithelium and neutrophils), as well as following cellular injury due to non-specific factors such as drugs, cancer and infection.

br Conclusion br Conflict of interest


Conflict of interest


Certain situations require the dentist to remove an anterior tooth. These conditions may include dental trauma, advanced periodontal disease, extensive root resorption, and endodontic failure. Whenever an anterior tooth is lost, the clinician should provide an immediate replacement to avoid aesthetic, masticatory, and phonetic difficulties and to prevent the drift of adjacent teeth. Conventional solutions to this problem have included the fabrication of a provisional restoration using the adjacent teeth as abutments, removable temporary acrylic prostheses, and resin-bonded bridges (Daly, 1983; Ashley and Holden, 1998; Safirstein et al., 2001). Various treatment modalities are available for the replacement of lost anterior teeth, such as orthodontic closure of the edentulous space with fixed appliances, ap4 of an osseointegrated dental implant, and the classical approach of a conventional fixed partial denture and removable prosthesis (Foitzik et al., 2007; Sangur et al., 2010). Each of these approaches has its own specific advantages and disadvantages in terms of usage, aesthetics, and compatibility.
A fixed, acid-etch bridge offers several advantages over removable appliances, including enhanced aesthetics, ease of use, and avoidance of having to become accustomed to a removable prosthesis (Fahl, 1998; Smidt, 2002; Chafaie and Portier, 2004). This approach would also permit the patient’s natural crown to be used as a pontic for an immediate bridge (Belli and Ozer, 2000), with little or no need for complicated laboratory procedures. The use of the extracted natural crown as a pontic provides the advantage of having the right size, shape, texture, and colour. Moreover, the patient is comforted by the presence of his or her natural tooth. The use of a modified resin-bonded bridge with a natural-tooth pontic provides additional advantages of aesthetic maintenance, tooth conservation, cost effectiveness, and preservation of the lost tooth’s gingival architecture.

Case report
A 24-year-old female patient reported to the Department of Conservative Dentistry and Endodontics with a complaint of a mobile maxillary right central incisor. The medical history of the patient was not significant. Dental history revealed an episode of trauma in the maxillary anterior region 5years ago. On clinical examination, the maxillary right central incisor showed grade III mobility, and the adjacent (left) central incisor was tender to percussion (Fig. 1a). The adjacent teeth were checked for vitality, and the maxillary left central incisor showed no response. For the right central incisor, radiographic examination revealed extensive root resorption and periradicular bone loss (Fig. 1b). X-rays also displayed widening of the periapical periodontal ligament of the left central incisor.

The present era of dentistry relies extensively on aesthetic principles because of increasing patient demands. A restorative dentist should try to meet these demands, while simultaneously considering the patient’s socioeconomic status. Immediate replacement of lost anterior teeth prevents psychological and social trauma to the patient. A resin composite may be used to splint the pontic to sound neighbouring teeth as a provisional restoration until the final prosthesis is fabricated. One major advantage of retaining the patient’s natural crown is brown algae the patient can better tolerate the effect of tooth loss (Ashley and Holden, 1998).

Ethical clearance

br Methods and subjects br Results

Methods and subjects


The majority of respondents preferred to learn in a traditional classroom setting with some electronic technologies used to access educational curriculum outside the classroom. It has been described that the traditional format is more convenient, it facilitates group activities and discussion, and it promotes the development of public health leadership (Dodds et al., 2003). Yet, this mode of education could be a barrier to those who cannot relocate to enroll in a graduate program (Dodds et al., 2003). Distant education programs in public health are offered at several universities in the United States, and some universities offer online master’s degrees in DPH to students concurrently enrolled in a school of dentistry accredited by the Commission on Dental Accreditation (CODA; ASPH Website). It is possible that offering elective courses through a distant education format may provide a good starting point for evolving a master’s program in DPH at KAUFD.
In general, most respondents were in favor of a bachelor’s degree in dentistry, followed by a bachelor’s degree in dental hygiene, as preferred prerequisites for graduate DPH education. Currently, the role of dental hygienists in DPH exceeds their role as dental educators. Hygienists in many parts of the developed world plan and administer DPH programs, are faculty members in cloprostenol dentistry departments, and are involved in DPH research (Burt and Eklund, 2005). Therefore, it is important that a graduate program in DPH in Saudi Arabia target dental hygienists as well as dentists.

Conclusions and implications for graduate DPH education
This assessment of the need for DPH graduate education comes at a time when many academic institutions across the country are realizing the impact of this dental specialty on a population’s oral health and well-being. For example, the College of Dentistry at King Saud University in Riyadh is considering restarting their DPH Masters Program, which was previously offered in 1993 and then was closed after graduating their first class (S. Al-Sadhan, personal communication, April 14, 2014). Meanwhile, Riyadh Colleges of Dentistry and Pharmacy (RCsCP), a private university, has been approved by the MOHE to start a master’s program in DPH (RCsDP website). The need for DPH education and practice is also advocated by schools of medicine throughout the country (Milaat, 2007). Correspondingly, several schools of medicine, as well as government organizations, have recently launched Masters in Public Health (MPH) programs. These programs are offered to physicians, dentists, dental hygienists, nurses, nutritionists, and other health professionals.
The majority of dental graduates in Saudi Arabia are employed by the MOH (MOH, Health Statistics Book, 2012). These dental practitioners are potential candidates for a master’s degree in DPH where the need for public health dentistry is greatest and the impact on the population’s oral health would be significant. However, despite these facts and the stated mission of the MOH that conforms with the purpose of a DPH program [“promotion of general health and prevention of diseases”, “performance monitoring in health institutions”, and “research activity…in the field of health investment”] (MOH website), the MOH does not finance, nor support, graduate DPH education. Rather, dentists affiliated with the MOH are persuaded to pursue graduate training in clinical dental specialty programs. The MOH’s reasons for declining applications to graduate DPH education are based on the discouraging experiences of formerly supported DPH specialists (M.A. Al-Rafee, personal communication, April 13, 2014). As a result, the denial of DPH applications by the MOH has turned away applicants who are truly interested and seeking a career in public health, as well as their access to scholarships to support this field of study.
In the United States, the Standards for Advanced Education Programs in DPH were formulated by the CODA of the ADA and pons require two years of graduate education in DPH. A dentist with an MPH degree from any school of public health that is accredited by the Council on Education for Public Health needs an additional year of training in DPH. This year usually consists of a one-year DPH residency in a program accredited by the CODA. Two-year educational programs are also offered exclusively at schools of dentistry that are accredited by the CODA. These programs provide a curriculum in general public health education in addition to residency training in DPH (Shulman et al., 1998). Accredited DPH residency programs prepare dental residents for a specialty examination that is conducted by the American Board of Dental Public Health (AAPHD website).

Introduction In recent decades advances in nanotechnology engineering

In recent decades, advances in nanotechnology engineering have given rise to the rapid development of many novel applications for nanoparticles (NPs) in various industries. Few studies, however, have been conducted to evaluate the health and safety implications of the introduction of these NPs into the workplace. The main concerns that NPs create in the workplace are the adverse effects of acute or chronic exposure. The lung is one of the main routes of entry for NPs into the body, making it a likely site for NP accumulation. Once NPs enter the interstitial air spaces, they are quickly taken up by alveolar Puromycin and are likely to induce toxic effects [1]. Thus, the need to create hazard identification and risk management strategies for these new products is of increasing importance.
Owing to the extremely small size of the NPs being used in industry, there is a concern that they may interact directly with macromolecules such as DNA. Objects on the nano scale take on novel properties and functions that differ markedly from those seen in their corresponding bulk counterparts, primarily because of their small sizes and large surface areas. Studies have revealed that the same properties that make NPs so unique could also be responsible for their potential toxicity [2].
Nanotechnology involves a wide range of physical and chemical properties, and many NPs are so dramatically new that they have highly unpredictable qualities. Employees involved in the development, production, and use of these new NPs are already exposed to unclear levels of toxicity. Occupational exposure to NPs could be associated with an increased risk of various cancers, as has been the case with occupational exposure to some metals. Although the exact mechanisms are not yet studied, there is accumulating evidence that reactive oxygen species (ROS) play important roles in the carcinogenetic effects of metals [3]. Oxidative stress-based biomarkers have been essential to comprehend how oxidative stress may be mediating the toxic effects of occupational exposure to many known carcinogenic substances.
There have been numerous studies demonstrating the induction of ROS following exposure to NPs. Both in vivo and in vitro studies have consistently found that NPs have biological effects on Puromycin the respiratory system, including the generation of oxidative stress, the induction of emphysema and proinflammatory status, and damage to DNA. Improved knowledge of such biological effects is needed to guide preventive strategies for the workplace [4].

Materials and methods
In this extensive literature review, relevant articles in the fields of toxicology (including in vitro and in vivo studies), industrial hygiene, and epidemiology were found using PubMed (http://www.ncbi.nlm.nih.gov.eleen.top/pubmed/), Google Scholar (http://scholar.google.com), and ScienceDirect (www.sciencedirect.com). Keywords were used to locate relevant articles, and the following is an example of a typical search: nanoparticle AND toxicology AND worker OR environment OR occupation AND health OR industry.

The increasing utilization of NPs in electronics and biomedicine demands an assessment of the risks associated with deliberate or accidental exposure to these substances, with metal-based NPs being the most important. Since the physical chemical properties such as the length and aspect ratio of NPs are linked to their genotoxicity, small NPs can induce primary DNA lesions at very low concentrations and this DNA damage is exclusively induced by oxidative stress. Particles with higher aspect ratios exhibited weaker genotoxicity wherein oxidative stress was a minor factor, and other mechanisms were likely involved [5]. When cells are exposed to NPs, they may undergo repairable oxidative stress and DNA damage or be induced into apoptosis, either of which may cause the cells to alter their proliferation, differentiation, or cell-to-cell signaling [6].
Studies in animal models indicate that silicate, titanium dioxide (TiO2), buckminsterfullerene (C60), carbon nanotubes, and particles produced by the combustion of wood or diesel oil produce elevated levels of lipid peroxidation products and oxidatively damaged DNA. Further, biomonitoring studies in humans have shown links between exposure to air pollution and oxidative damage to DNA. These results indicate that oxidative stress and elevated levels of oxidatively altered biomolecules are important intermediates that may be useful markers for characterizing the potential hazards of NP exposure [7].

According to Artazcoz et al the

According to Artazcoz et al [15], the conciliation of working life (employment) and family life (relatives) is a technique that can facilitate aspects of real equality between men and women and can reduce levels of tension and stress. Conciliation is aimed at obtaining a new distribution of social and economic systems in an organization where women can conciliate different aspects of their lives (work, family, and time dedicated to themselves) in a real way as much as men can. Therefore, the conciliation of work and family life contributes to a society because of improvements in the quality of life of both men and women, as well as Phos-tag of internal levels of stress within the organization. Other investigators such as Grote et al [16] highlighted the importance of the conciliation of work and family life in the context of caring for children at different stages, as well as how it can affect levels of stress within the family.
Finally, we examine sports and leisure activities, which are cushioning variables of stress that can, in many cases, reduce its negative effects. In their work Psicología social y ocio: una articulación necesaria (Social psychology and leisure: a necessary articulation) Rodríguez-Suárez and Agulló-Tomás [17] explained the importance of leisure in improving the quality of life and in reducing levels of stress. Other authors such as Stanton and Howard [18] and Stanton-Rich and Iso-Ahola [19] underlined the importance of leisure in the fight against burnout or overwork syndrome.

Materials and methods


We present in this section the most significant conclusions in relation to the cushioning variables that reduce the likelihood of high stress levels. When workloads are high and when family responsibilities are high (Fig. 2), the influence of cushioning variables are apparent when the work loads are high. In this case, when loads are high, that is, when working at high speed to meet tight deadlines for many hours each week, the probability of suffering stress is 57.69%. In this case, the probability of suffering stress may be improved from 57.69% to 16.09% if variables such as control and social support are considered (Fig. 2). The effect of the variable conciliation (Fig. 3) reduces the probability of suffering stress from 14.91% to 12.47%. In this case, much time is spent on childcare, caring for the elderly, and housework (high family loads). Moreover, the probability of suffering high levels of stress may be reduced from 34.06% to 25.11% through sports and leisure activities. It may be further reduced to 16.42% if the level of social support at work is high (Fig. 3).

Conflicts of interest


In many small and medium-sized enterprises (SMEs), awareness of the long-term health impacts of exposure to hazardous substances is low. This is despite recent estimates which show that in the European Union alone, 74,000 workers die every year as a result of occupational diseases caused by hazardous substances, and roughly ∼10 times more workers get an occupational disease [1]. Worldwide, ∼632,500 deaths and > 7 million lost healthy life years can be attributed to occupational exposure to hazardous substances each year [2]. For management and workers in SMEs, however, given their limited resources, urethra is not an easy task to comprehend the legal requirements related to controlling risks due to exposure to substances [3]. Besides, it is not an easy task to uncover the company-specific burden of disease related to this exposure, and to show the benefits that may be expected from interventions to reduce exposure.
In various countries, tools have been developed that support companies in preparing risk assessments and in selecting the proper risk management measures. One type of such tool, which has gained substantial interest and adoption worldwide, is control banding. Control banding is a qualitative risk assessment in which categories (“bands”) of hazards are combined with categories (bands) of the exposure potential, in order to arrive at risk estimates and—subsequently— recommended levels of controls [4,5]. Control banding approaches were first developed by the pharmaceutical industry in the late 1980s, and have found considerable application in risk management of substances [4,6]. One more recent application of control banding is to enable companies to prepare preliminary risk assessments for nanomaterials in the absence of firm toxicological and exposure data [5–7]. Control banding may be applied when uncertainty on hazards and exposure is high, but where nevertheless, more or less reliable estimations can be made by grouping the substances used in hazard categories and the activities carried out in exposure categories [6].

Tyrosine Kinase Inhibitor Library L chographie permet souvent de pr ciser le si ge

L’échographie permet souvent de préciser le siège et l’état évolutif du kyste. La classification de Gharbi en 5 stades des kystes hydatiques hépatiques [8] s’applique aux kystes hydatiques rénaux.
Les aspects du type II et III sont trés suggestifs du kyste hydatique. Le type I, le plus rencontré dans la majorité des séries pédiatriques publiées [9]), Tyrosine Kinase Inhibitor Library été trouvé dans 25% des cas de notre série.
Il peut être différencié d’un kyste séreux devant la présence d’une membrane propre épaisse. L’aspect pseudo-tumoral (type IV) soulève essentiellement le problème d’un cancer ou d’un abcès du rein. La notion de contage hydatique et l’absence de flux vasculaire en intra et péri-lésionnel à l’échodoppler sont en faveur de l’hydatidose. Le type V est suggestif d’un KH calcifié souvent stérile. L’uroscanner, pratiqué dans moins de 35% des cas selon les séries, apporte beaucoup de renseignements supplémentaires. Il s’avère nécessaire chaque fois que le diagnostic est incertain, surtout pour les kystes de type IV et I. Il permet de dresser un bilan topographique précis, de rechercher d’éventuelles localisations extrarénales et d’objectiver une éventuelle communication avec les voies excrétrices [10]. Dans notre série l’uroscanner a permis de visualiser une rupture du KHR dans 2 cas/6. L’imagerie par résonance magnétique n’est pas de pratique courante dans la maladie hydatique [11]. Elle trouverait sa justification quand l’imagerie en coupe ne permet pas d’établir un diagnostic certain. Le liquide vésiculaire est en hyposignal en T1 et en hypersignal en T2. Biologiquement, il existe une hyperéosinophilie dans 20 à 50% des cas [12]. La sérologie hydatique est utile, cependant sa positivité n’est rapportée que dans 60% des cas de KHR [13]. Dans notre série, en combinant 2 techniques, la sérologie était positive dans tous les cas.
De nouvelles techniques thérapeutiques moins invasives se basant sur la chirurgie vidéo-assistée et la chirurgie percutanée, ont fait leur apparition ces dernières années. La chirurgie vidéo-assistée, pratiquée dans 4 cas/8 des cas de notre série, a comporté 3 cas de laparoscopie et un cas de rétropéritonéoscopie pour KHR isolé. Cette chirurgie vidéo-assistée a Balbiani ring l’avantage d’être moins délabrante, ne nécessite qu’un court séjour post opératoire et ne semble pas exposer à plus de complications d’essaimage que la chirurgie ouverte car elle comporte exactement les mêmes précautions d’usage [14].
L’évolution post opératoire tardive est fréquemment favorable dans la littérature en dehors d’une récidive estimée à moins de 5% des cas [15].
Tous non malades ont été suivis en consultation avec un recul qui varie d’un an à 12ans et ½. La surveillance s’est basée sur des critères cliniques, échographiques et sérologiques. L’examen clinique était normal sans aucune gêne fonctionnelle pour tous les patients. Une échographie abdominale et une sérologie hydatique ont été demandées tous les six mois chez les patients régulièrement suivis. Le contrôle échographique a montré une restitution ad-integrum de la loge rénale dans 5 cas, l’apparition de calcifications dans 2 cas et la persistance d’une cavité résiduelle cicatricielle dans 1 cas après une année après le traitement chirurgical. La sérologie s’est négativée dans 3 cas/8.


Conflit d’intérêt


Les complications urologiques font partie de ces accidents, elles peuvent survenir lors d’une chirurgie carcinologique ou bénigne. En France la chirurgie gynécologique se complique dans 0,5 à 10% par des lésions urétérales [1]. Dans les meilleurs des cas la lésion urologique est identifiée en per opératoire, permettant une réparation immédiate. Mais dans la majorité des cas le diagnostic de la complication se fait quelques heures voire quelques jours après l’intervention chirurgicale. Toutes les spécialités touchant la cavité abdomino-pelvienne sont concernées par ces lésions iatrogènes notamment la chirurgie digestive, la chirurgie traumatologique et orthopédique, la chirurgie endoscopique, la chirurgie gynéco obstétricale. Même si l’attitude à adopter diffère, les accidents survenant lors de la chirurgie laparoscopique sont essentiellement les mêmes que ceux de la chirurgie ouverte [2].

procyanidin b2 La atm sfera se hizo pesada

La atmósfera se hizo pesada aunque pareciera un espejismo: ¿cómo era posible un rumor en el que se me involucraba como fuertemente hostil procyanidin b2 los ancianos? Precisamente las principales versiones relativas al rumor que se propagó consistían en: “hay una lista con los nombres de los ancianos que van a ser llevados en un camión, encerrados y matados”, “va a ser en la noche, se dice que un camión vendrá y que nos meterá adentro, por la fuerza si no queremos, son gentes del gobierno, nos van a conducir a un calabozo y después nos van a matar” (Rohrbach Viadas 1992: 203-204). El contenido temible del rumor se convirtió en una verdad. Este escenario me llevó a comprender que todo intento por negarlo era inútil y que era preferible entrar dentro del rumor y dialogar con los otros miembros de la comunidad. Cuando pude aceptar esto me presenté y serenamente mencioné: “me dicen que se van a llevar a los ancianos. Cuéntenme, ¿cómo va a ser esto? Me interesa comprender”. Con esta actitud aprendí progresivamente cómo se iban elaborando esos “ruidos confusos de voces” en torno mi persona. Como dice Kilani: “contrariamente al misionero que quiere dar todo y al antropólogo que quiere comprender todo, el ‘exotes’ de Segalen debe también saber recibir” (citado por Kilani 1994: 11). Mi actitud tranquilizó a los campesinos y favoreció el conocimiento del significado implícito de la ancianidad y mi relación con el resto del grupo.
Lo que interesa ahora es elucidar la concepción que este grupo de campesinos otorga a sus ancianos, así como la manera de simbolizarlos. Basándome en el contenido del rumor y en mis observaciones, una primera hipótesis parece indicar que la exclusión es el lugar reservado a los ancianos campesinos al postular que se les va a llevar lejos e inclusive que se les va a liquidar. Sin embargo, esta primera suposición requiere un estudio más penetrante para comprender la unidad que constituye esta sociedad. El contenido del rumor formula lo explícito, lo manifiesto de la situación tal como era comprendida, lo que corresponde a: “los ancianos han fallado a las normas de la comunidad al aceptar mis propuestas y mis privilegios y por eso se les va a eliminar”. Las comunidades campesinas consideran a los miembros de toda la comunidad como iguales y se distribuyen los privilegios para conservar la equidad amenazada por la desigualdad. Los campesinos van más lejos, como aquí lo vemos, ellos practican estos principios que mi actitud quebrantó: quienes aceptaron mis obsequios deben ser castigados.

Lectura interpretiva
Llegar a Primary transcript ser anciano es el futuro de todo ser humano a menos que un accidente o enfermedad grave lo impidan. Ser anciano en nuestro mundo actual que valora sobre todo la juventud implica necesariamente aprensiones e incertitudes por lo que su estudio interesa en las diversas sociedades del mundo. Se sugiere que estos estudios que “aíslen” a los ancianos como única categoría, invitando a realizar investigaciones que consideren a los ancianos dentro del contexto sociocultural al que pertenecen y los comparen con otros grupos sociales y con las demás categorías de edad. Si no es así, podemos caer en conceptos equivocados ya sea al idealizarlos, al despreciarlos, al compadecerlos o al minimizarlos. Estudiar a los ancianos comporta igualmente una comparación con uno mismo sobre los propios prejuicios y proyecciones hacia esta categoría de edad particularmente compleja debido a que la ancianidad ha perdido prestigio y a menudo no se aguarda con entusiasmo. Estudiar la ancianidad comporta dificultades suplementarias que es necesario examinar con detenimiento ya que este tema es como un “espejo proyectivo” en el que el investigador mira al otro proyectando, más fácilmente que con otras categorías de edad, sus miedos al igual que sus deseos (Alber y Bettosini 1984), el investigador se compara así con un espejo lejano y próximo.
El encuentro entre estas dos colectividades permite vislumbrar la vejez en su contexto sociocultural mostrando dos formas diferentes que pueden orientar y hacer comprender mejor este fenómeno a través de sus diferencias. Además el compadrazgo como práctica social relaciona al pueblo y a las rancherías formando precisamente esa unidad en la que pueblerinos y campesinos se sienten partícipes. El pueblo conlleva la imagen de admiración particular a las sociedades patriarcales que tienden a dar un estatuto positivo a sus ancianos (Simmons 1945, padre de la gerontología social, primer trabajo comparativo), aunque la concepción de la ancianidad y la posición del anciano están, como admirablemente lo subrayó Luis González (1979), “en vilo”, a lo que yo agregaría, además de la tradición patriarcal y la modernidad ya mencionados por González, el empirismo campesino.

La ilustraci n figura de este tetzahuitl en

La ilustración (figura 2) de este tetzahuitl en el Códice Florentino muestra exactamente su descripción: cinco hombres admiran la pirámide de fuego; con el dedo índice de una mano la señalan, mientras que la otra mano la conservan abierta kanamycin la altura de la boca. Se observa con claridad que una de las cinco personas tiene la boca abierta. Esta acción corporal representa el alarido indicado por el verbo tenhuitequi, que consiste en tapar y destaparse la boca –como se ha apuntado varias veces. Desgraciadamente, en la imagen sólo aparecen hombres, lo cual no nos permite establecer el contraste genérico de la expresión del miedo que se aprecia en las fuentes escritas.
Así como el verbo tenhuitequi comunicaba una acción en la guerra al tiempo que una demostración de terror ante una señal de mal agüero, la acción que comportaba el verbo tlacahuaca también se manifestaba en ambos contextos, pues refería a los alaridos o gritos de guerra (Molina 2004, sección náhuatl-español: fol. 115v; Siméon 2002: 561) y a un gesto de temor durante los fenómenos naturales aciagos, como el de la pirámide de fuego y el eclipse de sol (, lib. VII, cap. I: 2).
El gesto que refiere a la acción tenhuitequi igualmente tenía por objetivo avisar a los que no sabían que estaba temblando. Cuando temblaba: “todo mundo da gritos, grita pegándose en los labios, para avisar [que hay temblor] a quienes no lo saben” (Sahagún 1969b: 74-75). También era utilizado para infundir miedo en el enemigo durante la guerra (Torquemada 1975, I, lib. II, cap. XC: 320). Es posible que al ponerlo en práctica en las situaciones de miedo se tratara de alejar de sí el peligro.
Además de la guerra y las situaciones de miedo, podemos identificar un tercer contexto de aparición del verbo que venimos tratando: el de la inmoralidad. En un texto náhuatl del siglo xvii se registra la conversación entre una madre y una anciana sobre el comportamiento inmoral de uno de los hijos de aquélla. La madre cuenta que es “poco inteligente y travieso, luego nada teme […]; como si fuera chichimeca va pegándose en los labios, grita corriendo. Y en ningún lugar se para, luego va lejos, huye…” [in achi cueciuhqui, inniman amo tla imacaci […], yuhquin ma chichimecatl motenhuitectiuh tzatzitiuh in motlaloa: auh acan moquetza, niman hueca yauh choloa…] (Garibay 1943: 99).
La puesta en práctica del verbo tenhuitequi fuera de los contextos señalados para ello, denotaba el estado de locura y de inmoralidad del ejecutor, pues violaba las convenciones sociales de las expresiones corporales. Otras acciones que acompañan a Abundance dicho gesto y que enfatizan su situación transgresora es gritar, no temer ni respetar, correr y huir sin parar, actitudes que precisamente definieron el comportamiento físico del joven malvado, tal como se observa en una exhortación de un padre a su hijo recuperada por fray Andrés de Olmos (García Quintana 1974: 154-157).
Las diferentes maneras corporales de expresar el miedo entre los nahuas mantuvieron concordancia con lo que se esperaba de cada uno de los géneros y los grupos de edades, y con la concepción que se tenía de éstos. Si bien el llanto era una actitud generalizada ante variadas situaciones emotivas, en los contextos de miedo la expresión corporal de los hombres los distanciaba de las mujeres y los niños, quienes seguían manteniendo el lloro como forma de manifestar el temor (Muñoz Camargo 1998: 187). Esto hacía que ambos grupos sociales conformaran una unidad.
Esto es ejemplar en el caso de las parteras y las ancianas que llevaban custodiado el cuerpo de la mocihuaquetzqui –mujer muerta de primer parto– para enterrarlo frente a las imágenes de las diosas cihuapipiltin. La particularidad de estas mujeres es que iban portando escudos y gritando como si fueran a la guerra, gesto que es descrito por los informantes nahuas de Sahagún a través de los verbos tlacahuaca y tempapahuia (Sahagún 1969b: 142). Estos verbos indicaban los gritos que daba la gente, con seguridad los hombres, durante el eclipse solar (ibidem: 144).

br Aim br Methods This single arm


This single-arm prospective cohort pilot study (institutional review board approval number 12053-12-071; National Clinical Trials registry identification number NCT02070029) included premenopausal women with a primary diagnosis of HSDD given by a gynecologist or urogynecologist. Women 18 to 55 years old were eligible if sexually active (defined as at least four sexual encounters in the month before enrollment), were in a monogamous relationship, and had a documented diagnosis of HSDD as the primary cause of FSD (defined as a non-adjusted score ≤ 6 in the desire domain [range = 0–10] of the Female Sexual Function Index [FSFI] questionnaire). Exclusion criteria included postmenopausal women (defined as absence of menstruation in the prior 12 months), pelvic pain or dyspareunia as the primary cause of FSD (defined as a non-adjusted score ≤ 6 in the pain domain [range = 0–10] of the FSFI), prior hysterectomy and/or oophorectomy, history of chemotherapy and/or pelvic irradiation, use of hormonal contraception or hormone replacement therapy, active skin infection or disease preventing insertion of acupuncture needles, known allergy to acupuncture needles, or blood dyscrasia.

Main outcome measures

There are several proposed mechanisms of action for acupuncture. Older research reported a release of endorphins during therapy sessions, whereas more recent literature has focused on the physiologic effects of these endorphins on the Radicicol manufacturer as seen at functional magnetic resonance imaging. However, our study did not include laboratory data or brain imaging. Instead, we focused on symptomatic improvement. Acupuncture is widely used and has been studied as treatment for several chronic medical conditions, from migraines and pelvic pain syndromes such as dysmenorrhea to urinary incontinence and fertility issues, with improvement in patient symptoms. Similarly, we noted improvement in our subjects\’ symptoms, primarily that of low sexual desire. After intervention with acupuncture, we noted a much greater difference in our primary outcome measurement than was anticipated by our power analysis, which was based on intervention by specialist consultation alone. This could illustrate Radicicol manufacturer that acupuncture has a positive impact.
In general, most studies evaluating the efficacy of acupuncture assess patient symptomatology rather than hormone levels. Lammerink et al focused on the outcome measurements of self-reported hot flashes and impaired sexual functioning from breast cancer treatments after intervention with acupuncture. De Valois et al found improved vasomotor symptoms after acupuncture therapy. Our study focused on symptomatic improvement using validated questionnaires for a more robust assessment of change. Nonetheless, some rat model studies by Wang et al evaluated hypothalamic function after activation by acupuncture and showed increased electrical activity of excitatory neurons related to stimulation of sexual arousal. Although we did not use an animal model, our population included reproductive-age women similar to the research of Wang et al and our subjects reported increased sexual arousal. In addition, our study design focused on a single prospective cohort, similar to the research by De Valois et al, and included premenopausal women. However, the participants in the study by De Valois et al were taking tamoxifen, which could have influenced hormonal status regardless of age, and our study design controlled for this.
Research is lacking regarding the use of acupuncture for FSD. A systematic review from 2011 confirmed that the evidence was insufficient for drawing any positive conclusions about the application of acupuncture to improve FSD. In addition, the review concluded there was a considerable risk of bias. In contrast, our study found positive improvements in FSD and our methodology included stringent exclusion criteria. More recent research by Khamba et al in 2013 examined the benefit of acupuncture to manage sexual dysfunction secondary to antidepressant use. Although men and women of different ages were included, improvements were noted in libido and lubrication for the women. Interestingly, our study saw improvements in libido and lubrication with only 10 consecutive acupuncture sessions, whereas the protocol used by Khamba et al used 12. Furthermore, our study showed a modest decrease in symptom-related distress similar to the decrease of anxiety and depression in the subjects described by Khamba et al.

The domain of the problem is discretized and the

The domain of the problem is discretized and the boundary conditions for are replaced by and , where is a sufficiently large value of (corresponding to step size) at which the boundary conditions (19) for are satisfied. The authors ran the computer code written in MATLAB for different values of and for different values of step size . They found that there is no, or only a negligible, change in the quantities of physical interest like Nusselt number and buy EPZ5676 friction coefficients for values of greater than 3. Also, after the temperature is always zero. This means the numerical scheme is consistent and stable. Therefore, in the present work the authors have set and step size taking into account the consistency and stability criteria. To solve the problem the non-linear equation  (14)–(17) have been first converted into nine first order linear ordinary differential equations. There are five conditions at boundary (values of the function) and four conditions at boundary . To get the solution of the problem, one will need four more conditions at . These conditions have been found by the shooting technique. Finally the problem has been solved by the Runge–Kutta Fehlberg method along with calculated boundary conditions.

Results and discussion
In order to analyze the effects of various physical parameters on the flow, a numerical computation has been performed. To validate the results, the authors have compared the results with published work [9,14,15,23]. These comparisons are given in Tables 1 and 2. These results show that our resuts are in very good agreement with previously published work. The effects of various physical parameters on horizontal velocity, transverse velocity, angular velocity profiles and temperature distribution have been discussed and shown in Figures 2–18. The effects of all these parameters on local skin friction coefficients (due to horizontal velocity as well as transverse velocity) and local Nusselt number have been given in Tables 1–5.
The effect of or (the angle of wedge) on velocity profiles and temperature distribution are shown in Figures 2–4. It is depicted from Figure 2, that the horizontal velocity increases with m and the momentum boundary layer thickness decreases. This in turn increases the velocity gradient at the surface () and hence increases the skin friction coefficient. The skin friction coefficient for is largest. Thus, the skin friction coefficient near the stagnation point of a plate is largest in comparison to the flow past a horizontal plate () and the flow past a wedge (). This results in an increase in local Nusselt number as given in Table 3.
Figure 3 shows that as we move away from the surface of the wedge the absolute value of angular velocity decreases continuously for small values of . i.e. for and (wedge angle 90°). In case of , the absolute value of angular velocity first increases, but after a certain distance from the surface of the wedge it decreases. This figure also shows that the gradient of angular velocity near the surface increases with the increase in m and thus the shear stress increases with the increase in the angle of wedge.
Figure 4 depicts the effect of m on temperature distribution. The value of temperature at the surface increases slightly with the increase in the value of , but at it increases rapidly. However, as we move away from the surface the effect is just reversed. i.e. temperature decreases with the increase in m from to 1. From the graph it is also clear that, the thermal boundary layer thickness decreases with the increase in . Thus the heat transfer rate for the wedge with large angles is higher.
Figures 5–8 depict the effect of and on velocities and temperature distribution. Figure 5 depicts that with the increase in horizontal velocity increases slightly near the surface of the wedge, but after a certain buy EPZ5676 distance it decreases. This means the Hall current at the surface of the wedge enhances the fluid velocity slightly. This is because of the increase in Lorentz force near the surface of the wedge. This increases the velocity gradient near the wall and results in an increase in local skin friction coefficient .